Scodelario was born on March 13, 1992 to an English father and a Brazilian mother.Her parents divorced when she was a child and she was brought up by her mother, subsequently adopting her surname and becoming fluent in Portuguese.
Her father, Roger Humphrey, passed away on 22 November 2010. Scodelario was bullied during her early childhood and dealt with low self-esteem, so her passion for drama became an outlet for her.
She revealed on her Twitter account that she has dyslexia, saying, "Watching a interesting doc on BBC Three about dyslexia, something that I have struggled with my whole life. It really affected my self-esteem." Scodelario's mother's family lives in Itu, a city in São Paulo state, Brazil, and she visits as often as she can
With no prior acting experience, at the age of 14, Scodelario was cast in the 2007 first series of Skins as Effy Stonem. Upon Scodelario's arrival to the auditions she felt she was too young and became discouraged, but a producer stopped her before she could leave and asked her to read for the part.
While Scodelario's role had minimal speaking lines in the first series, her character developed considerably in the 2008 series, before she eventually became the central character in the 2009 series after the cast had been replaced with a new generation of characters.
This made Effy the only character to appear from series 1 right through to series 4 of Skins. She will reprise her role as Effy at some point during the seventh series of Skins
On 12 March 2009 it was announced on the official Skins website that a fourth series had been planned, for which Scodelario along with her co-stars, were to reprise their roles.
Filming began in July and Scodelario revealed that 18 November 2009 had been her last day of filming the series and that she would miss being on the show.
Scodelario left after the fourth series, making way for the third generation of characters.
Scodelario revealed in an interview that she dated Skins co-star Jack O'Connell for about a year before splitting in June 2009, though they remain good friends.
She has been in a relationship with Elliott Tittensor since late 2009.Their relationship became more prominent when Scodelario supported Tittensor during a court case he was facing. From 2008 until 2010,
Scodelario lived alone in a flat in North London, stating that it is important for women to be "independent and strong". She was voted 13th in the UK edition of FHM's 100 World's Sexiest Women 2010.